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New drugs with greater efficiency

New drugs with greater efficiency

Proteasome inhibitors

Proteasome is a cellular body responsible for removing protein no longer needed by the cell, thus giving the name 'cell's trash processor'. If proteasome functionality is inhibited, protein which should be removed accumulates in the cell. This interferes with the cell’s functionality and can cause it to die. Interestingly, cancer cells are 1000 times more susceptible to proteasome inhibitors compared to healthy cells. Drugs that stop 'cell's trash processor' are called proteasome inhibitors. Although they only target one cellular body, they affect numerous vital cellular processes, preventing development of cancer cells, their division and spread into other parts of the body.
Treating with proteasome inhibitors results in various possible side effects:  transient thrombocytopenia (reduced numbers of platelets), anemia, neutropenia (reduced number of white blood cells), herpes zoster, and peripheral neuropathy with pains in limbs, disturbances in the sense of touch, sensation of tingling and pins and needles in hands and feet can also be present. Peripheral neuropathy is partially or completely resolved in patients after the treatment has stopped or the drug dosage reduced.

Immunomodulatory drugs

Monoclonal antibodies

HDAC inhibitors

PHCZ/HEM/0717/0001