How is the treatment with biologics administered?
Prior to administering a biological, several tests are performed to establish the patient’s general health. Latent tuberculosis infection, hepatitis B and C, and HIV infections are to be ruled out. Regular check-ups with the dermatologist is necessary during treatment.
The most common side effect of this treatment is the reaction in the area of the administered injection. A mild reaction that does not influence the ongoing of the treatment is to be expected. Biological therapy patients are immune compromised, which means that they are at higher risk of developing serious infections.
The onset of any symptoms such as fever, cough, sweating, or fatigue has to be diagnosed and treated as soon as possible.
In addition to an increased risk of developing infections, patients are more susceptible to developing certain malignancies during long-term biologic treatment, which is minimal with novel biologics.
- Pathirana D, et al. J Eur Acad Dermatol Venereol 2009; Oct;23 Suppl 2:1-70.
- Nast A, et al. J Eur Acad Dermatol Venereol 2015; 29:2277-94.
- Hsu S, et al. Arch Dermatol 2012; 148:95-102.
- National Psoriasis Foundation website: https://www.psoriasis.org/biologics/ Accessed March 2021.
- Psoriasis Association SA Webpage: https://psoriasis.org.za/types-treatments/ Accessed March 2021.
- National Psoriasis Foundation Website: https://www.psoriasis.org/treatments-for-psoriatic-disease/ Accessed March 2021.
Recensed by assist. Katarina Trčko, MD, PhD; Department of Dermatology and Venereal Diseases, University Medical Centre Maribor